[委内瑞拉马脑炎病毒减毒株15对经呼吸道感染啮齿动物的保护活性]
[The protective activity of the attenuated strain 15 of the Venezuelan equine encephalomyelitis virus in rodent infection via the respiratory tract].
作者信息
Filatenkov A G, Khaltaeva G G, Khlebnikova N N, Gorban' S G, Shkurnikova N N, Khamitova M F
出版信息
Vopr Virusol. 1991 May-Jun;36(3):229-31.
PMID:1891877
Abstract
Administration to rodents (Syrian hamsters, mice, guinea pigs, rabbits) of minimal doses of attenuated strain 15 VEE (up to 20 ImD50) provided protection against respiratory challenge with a highly virulent strain of Venezuelan equine encephalomyelitis virus. The protection is observed in a wide range of doses (up to LD50 hundreds and even thousands).
摘要
给啮齿动物（叙利亚仓鼠、小鼠、豚鼠、兔子）注射最小剂量的减毒15型委内瑞拉马脑炎病毒株（高达20个免疫剂量50），可使其免受高毒力委内瑞拉马脑炎病毒株的呼吸道攻击。在很宽的剂量范围内（高达半数致死量的数百倍甚至数千倍）都能观察到这种保护作用。
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