减毒活疫苗和甲醛灭活委内瑞拉马脑炎病毒疫苗对仓鼠气溶胶攻击的保护效力。
Protective efficacies of live attenuated and formaldehyde-inactivated Venezuelan equine encephalitis virus vaccines against aerosol challenge in hamsters.
作者信息
Jahrling P B, Stephenson E H
出版信息
J Clin Microbiol. 1984 Mar;19(3):429-31. doi: 10.1128/jcm.19.3.429-431.1984.
Abstract
Although two investigational vaccines are used to immunize humans against Venezuelan equine encephalomyelitis virus, neither had previously been tested for protective efficacy against aerosol exposure. Live attenuated vaccine (TC-83) protected all hamsters challenged by either aerosol or subcutaneous routes with 4.7 to 5.2 log10 PFU of virulent Venezuelan equine encephalomyelitis virus. Formaldehyde-inactivated vaccine (C-84) failed to protect against aerosol challenge but did protect against subcutaneous challenge. Protection elicited by TC-83 vaccine did not depend solely on serum-neutralizing antibody. These studies suggest that TC-83 vaccine is preferable to C-84 vaccine for protecting laboratory workers at risk to aerosol exposure.
摘要
虽然有两种研究性疫苗用于人类免疫以抵抗委内瑞拉马脑炎病毒，但此前均未针对气溶胶暴露的保护效力进行过测试。减毒活疫苗（TC-83）可保护所有通过气溶胶或皮下途径用4.7至5.2 log10 PFU强毒委内瑞拉马脑炎病毒攻击的仓鼠。甲醛灭活疫苗（C-84）未能预防气溶胶攻击，但可预防皮下攻击。TC-83疫苗引发的保护作用并非仅取决于血清中和抗体。这些研究表明，对于有气溶胶暴露风险的实验室工作人员，TC-83疫苗比C-84疫苗更可取。
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