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[幼年特发性关节炎患儿的身体发育]

[Physical development in children with juvenile idiopathic arthritis].

作者信息

Umławska Wioleta, Michałowska Joanna, Podwysocka-Harasimowicz Maria

机构信息

Katedra Antropologii Uniwersytetu Wrocławskiego.

出版信息

Pediatr Endocrinol Diabetes Metab. 2008;14(3):161-4.

Abstract

INTRODUCTION

Juvenile chronic arthritis (JIA) is a major paediatric rheumatic disease.

AIM OF THE STUDY

The aim of this study was to determine how physical development in children with JIA was affected by the subtype of the disease and by the type of therapy used.

MATERIAL AND METHODS

Data were collected at the Sunbeam Center for the Diagnosis and Treatment of Childhood Illnesses in Wrocław, Poland. The study group included 82 children from 4 to 18 years old that were diagnosed with juvenile idiopathic arthritis. The duration of the disease ranged from 3 months to 15 years, with a mean of 2.9+/-2,8 years. At the time the subjects were examined, the disease was either very mild, inactive or in remission. Because the subjects varied in terms of age, all data were standardized and recorded in terms of numbers of standard deviations away from the age-specific and sex-specific means for the reference group, which consisted of healthy children and adolescents from Warsaw, Poland.

RESULTS

In the subjects in this study, height and weight were insignificantly lower than in their healthy peers. Body height and body weight were negatively affected only in children treated with corticosteroids for more than one year. Serious growth disorders were observed in 5 subjects (6%). Chest depth and chest width were significantly lower.

CONCLUSIONS

Strong relationship between the growth retardation and long-term steroid therapy has been pointed out.

摘要

引言

青少年慢性关节炎(JIA)是一种主要的儿童风湿性疾病。

研究目的

本研究的目的是确定JIA患儿的身体发育如何受到疾病亚型和所用治疗类型的影响。

材料与方法

数据收集于波兰弗罗茨瓦夫的阳光儿童疾病诊断与治疗中心。研究组包括82名4至18岁被诊断为幼年特发性关节炎的儿童。疾病持续时间从3个月到15年不等,平均为2.9±2.8年。在对受试者进行检查时,疾病要么非常轻微、不活跃,要么处于缓解期。由于受试者年龄不同,所有数据均进行了标准化处理,并以相对于参考组(由来自波兰华沙的健康儿童和青少年组成)的年龄和性别特异性均值的标准差数量来记录。

结果

在本研究的受试者中,身高和体重略低于其健康同龄人。仅在接受皮质类固醇治疗超过一年的儿童中,身高和体重受到负面影响。5名受试者(6%)出现严重生长障碍。胸深和胸宽明显较低。

结论

已指出生长发育迟缓与长期类固醇治疗之间存在密切关系。

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