Gould D H, McAllister M M, Savage J C, Hamar D W
Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University 80523.
Am J Vet Res. 1991 Jul;52(7):1164-9.
Nine 115- to 180-kg, hay-adapted, Holstein steers were fed an experimental diet with added sodium sulfate that induces polioencephalomalacia (PEM). Five calves developed the disease. Thiamine concentrations in blood, CSF, brain, and liver were not indicative of thiamine deficiency. The odor of hydrogen sulfide in eructated rumen gas was associated with the onset of PEM. Sulfide concentrations in rumen fluid were measured 1 or 2 times a week by 2 techniques. Sulfide concentrations progressively increased in all 9 calves after the feeding of the PEM-inducing diet commenced. The highest concentrations coincided with the onset of clinical signs of PEM and were significantly higher in the calves that developed PEM than in those that did not. This suggests that PEM can result from sulfide toxicosis following excess production of sulfide in the rumen.
选用9头体重115至180千克、适应干草饲养的荷斯坦公牛，给它们喂食添加了硫酸钠的实验性日粮，这种日粮会诱发脑灰质软化症（PEM）。5头小牛患上了这种疾病。血液、脑脊液、大脑和肝脏中的硫胺素浓度并无硫胺素缺乏的迹象。反刍的瘤胃气中硫化氢的气味与脑灰质软化症的发作有关。每周用两种技术对瘤胃液中的硫化物浓度进行1或2次测量。在开始喂食诱发脑灰质软化症的日粮后，所有9头小牛的硫化物浓度都逐渐升高。最高浓度与脑灰质软化症临床症状的发作时间一致，且患脑灰质软化症的小牛体内的硫化物浓度显著高于未患病的小牛。这表明，瘤胃中硫化物过量产生导致的硫化物中毒可能会引发脑灰质软化症。
