Wijdicks E F, Borleffs J C, Hoepelman A I, Jansen G H
Department of Neurology, University Hospital Utrecht, The Netherlands.
Ann Neurol. 1991 Jun;29(6):683-6. doi: 10.1002/ana.410290620.
A 28-year-old woman presented with progressive coma after being asymptomatic for 1 year after the demonstration of seropositivity for human immunodeficiency virus and high serum immunoglobulin G toxoplasma titers. Computed tomographic scanning showed multiple rounded cerebral hemorrhages and massive cerebral edema. Postmortem examination disclosed Toxoplasma gondii cysts scattered throughout the brain. An overwhelming fatal toxoplasmosis associated with multiple cerebral hemorrhages may be the first presentation of the acquired immunodeficiency syndrome. We raise the possibility that frequent neuroradiological monitoring may be indicated in asymptomatic human immunodeficiency virus-infected patients with high immunoglobulin G toxoplasma titers.
一名28岁女性在被证实人类免疫缺陷病毒血清学阳性且血清免疫球蛋白G弓形虫滴度高后无症状1年，随后出现进行性昏迷。计算机断层扫描显示多处圆形脑内出血和大量脑水肿。尸检发现弓形虫囊肿散在分布于整个大脑。与多处脑内出血相关的严重致命性弓形虫病可能是获得性免疫缺陷综合征的首发表现。我们提出，对于无症状的人类免疫缺陷病毒感染且免疫球蛋白G弓形虫滴度高的患者，可能需要频繁进行神经放射学监测。
