Ng S S, Yue W W, Oppermann U, Klose R J
The Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.
Cell Mol Life Sci. 2009 Feb;66(3):407-22. doi: 10.1007/s00018-008-8303-z.
Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals.
染色质的翻译后修饰正逐渐成为染色体过程中日益重要的调节因子。特别是，组蛋白赖氨酸和精氨酸甲基化在调节转录、维持基因组完整性以及促成表观遗传记忆方面发挥着重要作用。最近，用于分析组蛋白甲基化的新方法的应用、遗传模型系统的建立以及探究全基因组组蛋白修饰图谱的能力，都有助于明确组蛋白甲基化是如何促成这些过程的。在此，我们聚焦于我们对组蛋白甲基化系统理解的最新进展，并探讨动态组蛋白甲基化如何促进哺乳动物的正常细胞功能。
