Bencini P L, Galimberti M, Signorini M, Crosti C
Institute of First Dermatological Clinic and Pediatric Dermatology, University of Milan, Italy.
Arch Dermatol. 1991 Sep;127(9):1357-60.
A controlled prospective study of 2165 outpatients undergoing skin surgery was performed to evaluate the utility and the effects of several antibiotic schedules for prophylaxis of wound infections. The patients were divided into four groups. Twenty-three of the 541 group A patients, given no antibiotics, had wound infections. Eight of the 542 group B patients, given systemic antibiotics from immediately after surgery until the third day, had wound infections. Four of the 540 group C patients, treated only with local sterile antibiotic powder sprinkled into the wound during surgery, had wound infections develop, and only one infection occurred in the 542 group D patients given systemic antibiotics from 2 days before surgery until the second day after surgery. This last schedule was the best for prophylaxis of wound infections in contamination-prone regions. Local antibiotic administration is a simple method for prevention of infections in routine skin surgery.
对2165例接受皮肤手术的门诊患者进行了一项对照前瞻性研究，以评估几种抗生素给药方案预防伤口感染的效用和效果。患者被分为四组。A组541例患者未使用抗生素，其中23例发生伤口感染。B组542例患者从术后立即开始至第三天给予全身抗生素，有8例发生伤口感染。C组540例患者仅在手术期间在伤口撒布局部无菌抗生素粉剂，有4例发生伤口感染，而D组542例患者从手术前2天至术后第二天给予全身抗生素，仅发生1例感染。最后这种给药方案对于易污染部位的伤口感染预防效果最佳。局部应用抗生素是常规皮肤手术中预防感染的一种简单方法。
