Wagman L D, Tegtmeier B, Beatty J D, Kloth D D, Kokal W A, Riihimaki D U, Terz J J
City of Hope National Medical Center, Duarte, California 91010.
Surg Gynecol Obstet. 1990 Jan;170(1):12-6.
The ability of perioperative cefazolin to reduce the incidence of postoperative wound infection in patients undergoing ablative surgical treatment for carcinoma of the breast was tested in this prospective, randomized, double-blinded study. From May 1983 until December 1985, 118 women were divided into two groups at random. Group 1 consisted of 59 patients and received cefazolin and group 2 was made up of 59 patients who received a placebo. The groups were similar with respect to age, operative procedure, operative time and time to discharge after operation. Three infections occurred among those in group 1 and five among those in group 2 (p = 0.72). The time to onset of infection was delayed in the patients in group 1 versus those in group 2 (17.7 days versus 9.6 days, p = 0.04). Six of eight infections occurred in patients in whom an interval between biopsy and definitive surgical treatment was present. Prophylactic antibiotics in mammary operations did not reduce postoperative wound infections in this study.
在这项前瞻性、随机、双盲研究中，测试了围手术期使用头孢唑林对接受乳腺癌根治性手术治疗患者术后伤口感染发生率的影响。从1983年5月至1985年12月，118名女性被随机分为两组。第1组由59例患者组成，接受头孢唑林治疗；第2组由59例接受安慰剂治疗的患者组成。两组在年龄、手术方式、手术时间和术后出院时间方面相似。第1组有3例感染，第2组有5例感染（p = 0.72）。与第2组患者相比，第1组患者感染发生时间延迟（17.7天对9.6天，p = 0.04）。8例感染中有6例发生在活检与确定性手术治疗之间有间隔的患者中。本研究中，乳腺手术预防性使用抗生素并未降低术后伤口感染率。
