Simonetti Oriana, Marasca Samuele, Candelora Matteo, Rizzetto Giulio, Radi Giulia, Molinelli Elisa, Brescini Lucia, Cirioni Oscar, Offidani Annamaria
Clinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.
Clinic of Infectious Diseases, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.
AIMS Microbiol. 2022 Apr 24;8(2):125-137. doi: 10.3934/microbiol.2022011. eCollection 2022.
Biofilm formation at the level of a wound plays an important role in its chronicization. The difficulty of its eradication has driven research toward the discovery and synthesis of new molecules that can act on biofilm to promote wound healing. This narrative review focuses on alternative molecules that can act and promote the eradication of methicillin-resistant , taking into consideration its antibiotic resistance, virulence, tendency toward the tenacious colonization of wounds by biofilms, and its increased prevalence in both community and hospital settings. A selection of promising studies were reported, analyzing the in vitro and/or in vivo efficacy of bacteriophages, metal nanoparticles, RNAIII inhibiting peptide (RIP), synthetized RIP derivatives, proteinase K and hamamelitannin.
伤口处生物膜的形成在其慢性化过程中起着重要作用。其难以根除促使人们开展研究，以发现和合成能够作用于生物膜以促进伤口愈合的新分子。这篇叙述性综述聚焦于可作用并促进耐甲氧西林菌根除的替代分子，同时考虑到其抗生素耐药性、毒力、生物膜在伤口处顽强定植的倾向，以及其在社区和医院环境中日益增加的患病率。报告了一系列有前景的研究，分析了噬菌体、金属纳米颗粒、RNAIII抑制肽（RIP）、合成的RIP衍生物、蛋白酶K和金缕梅鞣质的体外和/或体内疗效。
