Leung Kwok Sui, Shi Hong Fei, Cheung Wing Hoi, Qin Ling, Ng Wai Kin, Tam Kam Fai, Tang Ning
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People's Republic of China.
J Orthop Res. 2009 Apr;27(4):458-65. doi: 10.1002/jor.20753.
Fracture healing is a biological regenerative process that follows a well-orchestrated sequence. Most healing is uneventful and enhancement of normal fracture healing is not commonly done, although it is clinically important in the recovery and regain of functions after fracture. This study investigated the osteogenic effect of low-magnitude high-frequency vibration (LMHFV, 35 Hz, 0.3 g) on the enhancement of fracture healing in rats with closed femoral shaft fracture by comparing with sham-treated control. Assessments with plain radiography, micro-CT as well as histomorphometry showed that the amount of callus was significantly larger (p = 0.001 for callus area, 2 weeks posttreatment); the remodeling of the callus into mature bone was significantly faster (p = 0.039, 4 weeks posttreatment) in the treatment group. The mechanical strength of the healed fracture in the treatment group at 4 weeks was significantly greater (p < 0.001). The results showed the acceleration of callus formation, mineralization, and fracture healing in the treatment group. It is concluded that LMHFV enhances healing in the closed femoral shaft fracture in rats. The potential clinical advantages shall be confirmed in the subsequent clinical trials.
骨折愈合是一个遵循精心编排顺序的生物再生过程。大多数愈合过程顺利，通常不会特意促进正常骨折愈合，尽管在骨折后功能的恢复和重新获得方面它在临床上很重要。本研究通过与假处理对照组比较，研究了低强度高频振动（LMHFV，35Hz，0.3g）对闭合性股骨干骨折大鼠骨折愈合增强的成骨作用。X线平片、显微CT以及组织形态计量学评估显示，骨痂量显著更大（治疗后2周，骨痂面积p = 0.001）；治疗组骨痂重塑为成熟骨的速度显著更快（治疗后4周，p = 0.039）。治疗组4周时愈合骨折的力学强度显著更高（p < 0.001）。结果显示治疗组骨痂形成、矿化和骨折愈合加速。得出的结论是，LMHFV可促进大鼠闭合性股骨干骨折的愈合。其潜在的临床优势应在后续临床试验中得到证实。
