颅脑放射治疗与海马神经发生损伤
Cranial radiation therapy and damage to hippocampal neurogenesis.
作者信息
Monje Michelle
机构信息
Department of Neurology, Stanford University, Stanford Advanced Medicine Center, Palo Alto, California 94305, USA.
出版信息
Dev Disabil Res Rev. 2008;14(3):238-42. doi: 10.1002/ddrr.26.
DOI:10.1002/ddrr.26
PMID:18924155
Abstract
Cranial radiation therapy is associated with a progressive decline in cognitive function, prominently memory function. Impairment of hippocampal neurogenesis is thought to be an important mechanism underlying this cognitive decline. Recent work has elucidated the mechanisms of radiation-induced failure of neurogenesis. Potential therapeutic interventions are emerging.
摘要
颅脑放射治疗与认知功能的逐渐下降有关，尤其是记忆功能。海马神经发生受损被认为是这种认知下降的重要潜在机制。最近的研究阐明了辐射诱导神经发生失败的机制。潜在的治疗干预措施正在出现。
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