Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea.
Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
Brain Behav Immun. 2015 Mar;45:287-96. doi: 10.1016/j.bbi.2015.01.007. Epub 2015 Jan 14.
Cranial irradiation (IR) is commonly used for the treatment of brain tumors but may cause disastrous brain injury, especially in the hippocampus, which has important cognition and emotional regulation functions. Several preclinical studies have investigated the mechanisms associated with cranial IR-induced hippocampal dysfunction such as memory defects and depression-like behavior. However, current research on hippocampal dysfunction and its associated mechanisms, with the ultimate goal of overcoming the side effects of cranial radiation therapy in the hippocampus, is still very much in progress. This article reviews several in vivo studies on the possible mechanisms of radiation-induced hippocampal dysfunction, which may be associated with hippocampal neurogenesis, neurotrophin and neuroinflammation. Thus, this review may be helpful to gain new mechanistic insights into hippocampal dysfunction following cranial IR and provide effective strategies for potential therapeutic approaches for cancer patients receiving radiation therapy.
颅部照射（IR）常用于治疗脑肿瘤，但可能导致灾难性的脑损伤，特别是在海马体中，海马体具有重要的认知和情绪调节功能。几项临床前研究已经研究了与颅部 IR 诱导的海马功能障碍相关的机制，如记忆缺陷和类似抑郁的行为。然而，目前关于海马功能障碍及其相关机制的研究，其最终目标是克服颅部放射治疗在海马体中的副作用，仍在进行中。本文综述了几项关于辐射诱导海马功能障碍的可能机制的体内研究，这些机制可能与海马神经发生、神经营养因子和神经炎症有关。因此，这篇综述可能有助于深入了解颅部 IR 后海马功能障碍的机制，并为接受放射治疗的癌症患者提供潜在治疗方法的有效策略。
