Palmer Shawna L
Department of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
Dev Disabil Res Rev. 2008;14(3):203-10. doi: 10.1002/ddrr.32.
The population of survivors following diagnosis and treatment for medulloblastoma is thankfully on the rise. An increased focus on the quality of that survivorship has expanded the concept of cure to include efforts aimed at improving long-term cognitive outcome. It is well established in the literature that decline in overall intellect and academic performance is experienced by a majority of those undergoing treatment for pediatric medulloblastoma. This decline is believed to be secondary to decline in core cognitive abilities, which in turn are related to underlying damage to neuroanatomical substrates. A review of research on neurodevelopmental impacts following diagnosis and treatment for pediatric medulloblastoma is presented. Particular consideration is given to studies recently published that also reflect critical collaboration among those within the fields of neuropsychology and neuro-imaging. Results from the review are combined within a conceptual model upon which to guide future research and clinical efforts.
髓母细胞瘤诊断和治疗后幸存者的数量所幸正在增加。对这种生存质量的日益关注已将治愈的概念扩大到包括旨在改善长期认知结果的努力。文献中明确指出，大多数接受小儿髓母细胞瘤治疗的患者会出现整体智力和学业成绩下降的情况。这种下降被认为是核心认知能力下降的继发结果，而核心认知能力下降又与神经解剖学基质的潜在损伤有关。本文对小儿髓母细胞瘤诊断和治疗后神经发育影响的研究进行了综述。特别关注了最近发表的研究，这些研究也反映了神经心理学和神经影像学领域之间的关键合作。综述结果被整合到一个概念模型中，以指导未来的研究和临床工作。
