[波兰2至5岁肾病综合征患儿鼻咽部肺炎链球菌携带情况]

[Carriage of Streptococcus pneumoniae in nasopharynx in children with nephrotic syndrome aged 2-5 years in Poland].

作者信息

Szmigielska Agnieszka, Roszkowska-Blaim Maria, Wasilewska Anna, Tyl Joanna, Ogarek Iwona, Borzecka Halina, Czupryniak Aneta, Krynicki Tomasz, Cieślak-Puchalska Anna, Medyńska Anna, Morawiec-Knysak Aurelia

机构信息

Katedra i Klinika Pediatrii i Nefrologii WUM, Warszawa.

出版信息

Pol Merkur Lekarski. 2008;24 Suppl 4:32-4.

PMID:18924498

Abstract

Children with nephrotic syndrome (NS) are at increased risk of Streptococcus pneumoniae infections. Streptococcus pneumoniae carrier state in the nasopharynx is an early stage of this infections. The aim of the study was to assess carriage rate and characterise bacterial isolates of Streptococcus pneumoniae among children with NS in a prospective multicentre study involving 10 nephrologic centres in Poland. We studied 95 children including 56 boys (59%) i 39 girls (41%) with NS in mean age 3 i 7/12 +/- 11 miesiecy. All children had throat and nasopharynx swabs taken in two epidemiological seasons (Oct-Dec 2006 and Feb-Apr 2007). Streptococcus pneumoniae isolates were serotyped with PCR. Carriage of Streptococcus pneumoniae was diagnosed in 13 children (13.7%) including 13 boys (100%). Following serotypes were found: 6B (38.5%), 9V (15.3%), 23F (15.3%), 19F (7.6%). There were 23.3% isolates without identifiable serotype. Carriage of Streptococcus pneumoniae was diagnosed mostly in boys with NS. Serotype 6B was dominant in this age group.

摘要

患有肾病综合征（NS）的儿童感染肺炎链球菌的风险增加。鼻咽部肺炎链球菌携带状态是这种感染的早期阶段。本研究的目的是在一项涉及波兰10个肾病中心的前瞻性多中心研究中，评估NS患儿中肺炎链球菌的携带率并对细菌分离株进行特征分析。我们研究了95名儿童，其中包括56名男孩（59%）和39名女孩（41%），平均年龄为3岁7个月±11个月。所有儿童在两个流行季节（2006年10月至12月和2007年2月至4月）采集了咽喉和鼻咽拭子。肺炎链球菌分离株通过聚合酶链反应（PCR）进行血清分型。13名儿童（13.7%）被诊断为肺炎链球菌携带，其中包括13名男孩（100%）。发现的血清型如下：6B（38.5%）、9V（15.3%）、23F（15.3%）、19F（7.6%）。有23.3%的分离株无法鉴定血清型。肺炎链球菌携带主要在患有NS的男孩中被诊断出来。血清型6B在这个年龄组中占主导地位。