Clemen Christoph S, Rybakin Vasily, Eichinger Ludwig
Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Strasse 52, Cologne, Germany.
Subcell Biochem. 2008;48:1-5. doi: 10.1007/978-0-387-09595-0_1.
The coronins, first described in Dictyostelium discoideum in 1991, have meanwhile been detected in all eukaryotes except plants. They belong to the superfamily of WD40-repeat proteins and represent a large family of proteins, which are often involved in cytoskeletal functions. Phylogenetic studies clearly distinguish 12 subfamilies of which six exclusively occur in vertebrates. In the present book we have made a sincere attempt to provide a comprehensive overview on all aspects of coronin proteins including history, structure, subcellular localization and function in different organisms. In addition, we also included a general overview on the WD40 family of proteins and the structurally related Kelch family. The book should be of interest for scientists outside the field, but is more importantly intended as a fast and competent guide for newcomers as well as doctoral and postdoctoral scientists to coronin research in all its facets.
冠蛋白于1991年首次在盘基网柄菌中被描述，目前已在除植物外的所有真核生物中被检测到。它们属于WD40重复蛋白超家族，是一大类蛋白质，常参与细胞骨架功能。系统发育研究明确区分出12个亚家族，其中6个仅存在于脊椎动物中。在本书中，我们真诚地尝试全面概述冠蛋白的各个方面，包括其历史、结构、亚细胞定位以及在不同生物体中的功能。此外，我们还对WD40蛋白家族和结构相关的kelch家族进行了总体概述。这本书不仅会引起该领域外科学家的兴趣，更重要的是，它旨在为新入行的人以及博士生和博士后科学家提供一本快速且全面的指南，帮助他们了解冠蛋白研究的各个方面。
