Malagari Katerina
University of Athens, Papagou, Athens, Greece.
Expert Rev Anticancer Ther. 2008 Oct;8(10):1643-50. doi: 10.1586/14737140.8.10.1643.
The advantage of chemoembolization of the liver as an antineoplastic treatment for hepatocellular carcinoma is that it achieves high intratumoral concentrations of the chemotherapeutic agent locally that cannot be reached with systemic chemotherapy in nontoxic doses. However, chemotherapeutic release and local concentrations cannot be standardized by this technique. Drug-eluting beads have predictable pharmacokinetics and can achieve higher doses of the chemotherapeutic and prolonged contact time with cancer cells. The DC Bead is a drug-eluting bead that has proven favorable kinetics and clinical characteristics. This review describes the features of the DC Bead loaded with doxorubicin for the treatment of hepatocellular carcinoma.
肝动脉化疗栓塞作为肝细胞癌的一种抗肿瘤治疗方法，其优势在于能在局部肿瘤内达到高浓度的化疗药物，而全身化疗在无毒剂量下无法达到这一浓度。然而，这种技术无法使化疗药物的释放和局部浓度标准化。药物洗脱微球具有可预测的药代动力学，并且能够实现更高剂量的化疗药物以及与癌细胞更长的接触时间。DC微球是一种已被证明具有良好动力学和临床特性的药物洗脱微球。本综述描述了载有多柔比星的DC微球用于治疗肝细胞癌的特点。
