Dehghan Abbas, van Hoek Mandy, Sijbrands Eric J G, Oostra Ben A, Hofman Albert, van Duijn Cornelia M, Witteman Jacqueline C M
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
BMC Med. 2008 Oct 16;6:30. doi: 10.1186/1741-7015-6-30.
Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI). We examined the SNPs in relation to the risk of CHD and MI in a large population based study of elderly population.
The Rotterdam Study is a population-based, prospective cohort study among 7983 participants aged 55 years and older. Associations of the polymorphisms with CHD and MI were assessed by use of Cox proportional hazards analyses.
In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274. The corresponding HRs were 1.03 (0.90, 1.18) and 0.93 (0.81, 1.06) for the G allele of rs10757278. The association of the SNPs with CHD and MI was not significant in any of the subgroups of CHD risk factors.
we were not able to show an association of the studied SNPs with risks of CHD and MI. This may be due to differences in genes involved in the occurrence of CHD in young and older people.
近期全基因组关联（GWA）研究发现，细胞周期蛋白依赖性激酶2基因A（CDK2NA）和细胞周期蛋白依赖性激酶2基因B（CDK2NB）区域的两个单核苷酸多态性（SNP）（rs10757278和rs10757274）与冠心病（CHD）和心肌梗死（MI）风险持续相关。我们在一项针对老年人群的大型基于人群的研究中，检测了这些SNP与CHD和MI风险的关系。
鹿特丹研究是一项基于人群的前瞻性队列研究，共有7983名年龄在55岁及以上的参与者。通过Cox比例风险分析评估多态性与CHD和MI的关联。
在加性模型中，rs10757274的G等位基因每增加一个拷贝，经年龄和性别调整后的CHD和MI风险比（HRs）（95%置信区间）分别为1.03（0.90，1.18）和0.94（0.82，1.08）。rs10757278的G等位基因对应的HRs分别为1.03（0.90，1.18）和0.93（0.81，1.06）。在任何CHD风险因素亚组中，这些SNP与CHD和MI的关联均不显著。
我们未能证明所研究的SNP与CHD和MI风险之间存在关联。这可能是由于年轻人和老年人CHD发生过程中涉及的基因存在差异。
