冠心病中Rs10757274基因多态性：一项系统评价和荟萃分析。
Rs10757274 gene polymorphisms in coronary artery disease: A systematic review and a meta-analysis.
作者信息
Xu Lang-Biao, Zhang Yi-Qing, Zhang Nan-Nan, Li Biao, Weng Jia-Yi, Li Xiao-Yang, Lu Wen-Chao, Yu Pei-Ran, Wang Xi, Li Yuan, Han Zhen, Chen Lu, He Hong-Tao, Zhou Ya-Feng, Ma Xue-Xing, Xu Gui-Dong
机构信息
Department of Cardiology, Suzhou Municipal Hospital, Nanjing Medical University.
Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou City 215006, Jiang su Province, PR China.
出版信息
Medicine (Baltimore). 2020 Jan;99(3):e18841. doi: 10.1097/MD.0000000000018841.
BACKGROUND
It has been reported the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2BAS1) might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to investigate the association between rs10757274 polymorphism and the risk of CAD.
OBJECTIVES
The present study aimed to investigate the relationship between rs10757274 polymorphism and the risk of CAD.
METHODS
All studies of the rs10757274 SNP with CAD that were published between 2007 and 2018 were retrieved from the PubMed database. Meta-analysis was performed with Stata 14.0 software. The effect size of the rs10757274 SNP with CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI).
RESULTS
Eleven studies including 52,209 subjects (cases: 7990, controls: 44,219) were included in the final data combination. Pooled overall analyses showed that rs10757274 (allele model: P < .001; dominant model: P < .001; recessive model: P < .001; Heterozygote codominant: P = .002; Homozygote codominant: P < .001) polymorphisms were significantly associated with the likelihood of CAD. Significant heterogeneity between individual studies appears in all 5 models. Further subgroup analyses revealed that rs10757274 polymorphisms were all significantly correlated with the likelihood of CAD and no heterogeneity were observed in West Asians.
CONCLUSIONS
Our findings indicated that rs10757274 polymorphisms may serve as genetic biomarkers of CAD, especially in West Asians.
背景
据报道，rs10757274单核苷酸多态性（存在于CDKN2BAS1基因的9p21位点）可能与冠状动脉疾病（CAD）易感性相关。由于结果不一且尚无定论，我们进行了一项荟萃分析，以研究rs10757274多态性与CAD风险之间的关联。
目的
本研究旨在探讨rs10757274多态性与CAD风险之间的关系。
方法
从PubMed数据库中检索2007年至2018年间发表的所有关于rs10757274单核苷酸多态性与CAD的研究。使用Stata 14.0软件进行荟萃分析。基于比值比（OR）并计算95%置信区间（CI）来评估rs10757274单核苷酸多态性与CAD风险的效应大小。
结果
最终数据合并纳入了11项研究，共52209名受试者（病例：7990例，对照：44219例）。汇总的总体分析表明，rs10757274（等位基因模型：P＜0.001；显性模型：P＜0.001；隐性模型：P＜0.001；杂合子共显性：P = 0.002；纯合子共显性：P＜0.001）多态性与CAD可能性显著相关。在所有5种模型中，各研究之间均存在显著异质性。进一步的亚组分析显示，rs10757274多态性均与CAD可能性显著相关，且在西亚人群中未观察到异质性。
结论
我们的研究结果表明，rs10757274多态性可能作为CAD的遗传生物标志物，尤其是在西亚人群中。
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