Sharif Omar, Knapp Sylvia
Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Immunobiology. 2008;213(9-10):701-13. doi: 10.1016/j.imbio.2008.07.008. Epub 2008 Sep 7.
Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection.
髓系细胞触发受体（TREM）蛋白在先天性免疫和适应性免疫中发挥重要作用。自2000年发现TREM-1和TREM-2以来，该领域在过去8年中发展迅速，目前TREM-1被认为是免疫反应的放大器，而TREM-2被认为是负调节因子。在此，我们讨论TREM相关文献的现状，重点关注TREM-1和TREM-2及其表达、在单核吞噬细胞中的信号传导以及在先天性免疫和细菌感染中的作用。
