Wang Yong, Gao Linlin, Meng Lingxin
Department of Anesthesia, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Am J Emerg Med. 2008 Oct;26(8):898-901. doi: 10.1016/j.ajem.2008.04.017.
To investigate if naloxone combined with epinephrine can increase the resuscitation rate in cardiac arrest rat models induced by asphyxia.
Twenty-four rats were allocated into SA group (treated with 1 mL of saline, n = 8), EP group (treated with epinephrine 5 microg/100g, n = 8), and NA group (treated with epinephrine 5 microg/100g in combination with naloxone100 microg/100g, n = 8). Eight minutes after asphyxia, cardiopulmonary resuscitation was initiated, and different drugs were used in different groups at the same time.
Rates of restoration of spontaneous circulation (ROSC) were 25%, 75%, and 87.5% in SA, EP, and NA groups, respectively. The rate of ROSC in the NA group was significantly higher than that in the other 2 experimental groups (P < .05). The average resuscitation time in the NA group was much lower than that in the other 2 cohorts.
The administration of epinephrine alone may increase early resuscitation rate in a cardiac arrest model compared with placebo group. Moreover, the combination of naloxone and epinephrine may significantly increase resuscitation rate. The duration of ROSC in combination group is much shorter than that in the other 2 groups.
研究纳洛酮联合肾上腺素能否提高窒息诱导的心脏骤停大鼠模型的复苏率。
将24只大鼠分为SA组（用1 mL生理盐水处理，n = 8）、EP组（用5 μg/100g肾上腺素处理，n = 8）和NA组（用5 μg/100g肾上腺素联合100 μg/100g纳洛酮处理，n = 8）。窒息8分钟后开始心肺复苏，不同组同时使用不同药物。
SA组、EP组和NA组的自主循环恢复（ROSC）率分别为25%、75%和87.5%。NA组的ROSC率显著高于其他2个实验组（P < 0.05）。NA组的平均复苏时间远低于其他2组。
与安慰剂组相比，单独使用肾上腺素可能会提高心脏骤停模型的早期复苏率。此外，纳洛酮和肾上腺素联合使用可能会显著提高复苏率。联合组的ROSC持续时间比其他2组短得多。
