Faculdade de Medicina da Universidade de São Paulo, Department of Emergency Medicine, Research Laboratory, São PauloSP, Brazil.
Clinics (Sao Paulo). 2013;68(8):1146-51. doi: 10.6061/clinics/2013(08)14.
To evaluate the hemodynamic and metabolic effects of terlipressin and naloxone in cardiac arrest.
Cardiac arrest in rats was induced by asphyxia and maintained for 3.5 minutes. Animals were then resuscitated and randomized into one of six groups: placebo (n = 7), epinephrine (0.02 mg/kg; n = 7), naloxone (1 mg/kg; n = 7) or terlipressin, of which three different doses were tested: 50 µg/kg (TP50; n = 7), 100 µg/kg (TP100; n = 7) and 150 µg/kg (TP150; n = 7). Hemodynamic variables were measured at baseline and at 10 (T10), 20 (T20), 30 (T30), 45 (T45) and 60 (T60) minutes after cardiac arrest. Arterial blood samples were collected at T10, T30 and T60.
The mean arterial pressure values in the TP50 group were higher than those in the epinephrine group at T10 (165 vs. 112 mmHg), T20 (160 vs. 82 mmHg), T30 (143 vs. 66 mmHg), T45 (119 vs. 67 mmHg) and T60 (96 vs. 66.8 mmHg). The blood lactate level was lower in the naloxone group than in the epinephrine group at T10 (5.15 vs. 10.5 mmol/L), T30 (2.57 vs. 5.24 mmol/L) and T60 (2.1 vs. 4.1 mmol/L).
In this rat model of asphyxia-induced cardiac arrest, terlipressin and naloxone were effective vasopressors in cardiopulmonary resuscitation and presented better metabolic profiles than epinephrine. Terlipressin provided better hemodynamic stability than epinephrine.
评估特利加压素和纳洛酮在心脏骤停中的血流动力学和代谢效应。
通过窒息诱导大鼠心脏骤停，并维持 3.5 分钟。然后，动物复苏并随机分为六组之一：安慰剂（n = 7）、肾上腺素（0.02 mg/kg；n = 7）、纳洛酮（1 mg/kg；n = 7）或特利加压素，其中测试了三种不同剂量：50 µg/kg（TP50；n = 7）、100 µg/kg（TP100；n = 7）和 150 µg/kg（TP150；n = 7）。在心脏骤停后 10（T10）、20（T20）、30（T30）、45（T45）和 60（T60）分钟测量血流动力学变量。在 T10、T30 和 T60 采集动脉血样。
TP50 组的平均动脉压值在 T10（165 对 112 mmHg）、T20（160 对 82 mmHg）、T30（143 对 66 mmHg）、T45（119 对 67 mmHg）和 T60（96 对 66.8 mmHg）时高于肾上腺素组。纳洛酮组的血乳酸水平在 T10（5.15 对 10.5 mmol/L）、T30（2.57 对 5.24 mmol/L）和 T60（2.1 对 4.1 mmol/L）时低于肾上腺素组。
在这种窒息诱导的大鼠心脏骤停模型中，特利加压素和纳洛酮在心肺复苏中是有效的血管加压药，其代谢谱优于肾上腺素。特利加压素比肾上腺素提供更好的血流动力学稳定性。
