Hakmé Antoinette, Wong Heng-Kuan, Dantzer Françoise, Schreiber Valérie
Université Strasbourg 1, Institut Gilbert Laustriat, CNRS-UMR 7175, ESBS, Boulevard Sébastien Brant, BP 10413, F-67412 Illkirch Cedex, France.
EMBO Rep. 2008 Nov;9(11):1094-100. doi: 10.1038/embor.2008.191. Epub 2008 Oct 17.
Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid-like molecule poly(ADP-ribose) (PAR) has been known for 40 years, understanding its biological functions--originally thought to be only the regulation of chromatin superstructure when DNA is broken--is still the subject of intense research. Here, we review the mechanisms controlling the biosynthesis of this complex macromolecule and some of its main biological functions, with an emphasis on the most recent advances and hypotheses that have developed in this rapidly growing field.
聚（ADP-核糖）化是一种由聚（ADP-核糖）聚合酶（PARP）介导的蛋白质翻译后修饰。尽管核酸样分子聚（ADP-核糖）（PAR）的存在和性质已为人所知40年，但对其生物学功能的理解——最初认为仅在DNA断裂时对染色质超结构起调节作用——仍是深入研究的课题。在此，我们综述了控制这种复杂大分子生物合成的机制及其一些主要生物学功能，重点介绍了在这个快速发展的领域中取得的最新进展和提出的假说。
