Schwanzel-Fukuda M, Pfaff D W
Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10021.
J Steroid Biochem Mol Biol. 1991 Oct;39(4B):565-72. doi: 10.1016/0960-0760(91)90254-3.
Nerve cells that express luteinizing hormone-releasing hormone (LHRH), essential for reproductive functions, originate in the epithelium of the medial olfactory placode. While the peripheral origin of this physiologically important brain peptide is surprising, associations between olfactory and reproductive systems are well documented in behavioral studies of pheromones and in clinical studies of disorders including hypogonadotropic hypogonadism with anosmia or olfactory-genital dysplasia. Mechanisms underlying this migration include a close association with neural cell adhesion molecules (NCAM), but are likely also to involve other physical and chemical factors.
表达促黄体生成素释放激素（LHRH）的神经细胞对生殖功能至关重要，它们起源于内侧嗅基板的上皮。虽然这种对生理功能很重要的脑肽的外周起源令人惊讶，但嗅觉和生殖系统之间的关联在信息素的行为研究以及包括伴有嗅觉丧失的低促性腺激素性性腺功能减退或嗅觉-生殖器发育异常等疾病的临床研究中已有充分记录。这种迁移背后的机制包括与神经细胞黏附分子（NCAM）密切相关，但可能也涉及其他物理和化学因素。
