Li Guo-Hui, Huang Si-Yong, Kang Zhi-Jie, Xu Heng, Liang Ying-Min
Department of Hematology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1227-31.
Ex vivo expansion of hematopoietic progenitor cells (HPCs) is valuable for clinical application, however, traditional ex vivo culture negatively affects long-term hematopoietic reconstitution ability. In the hematopoietic system, the expression of Notch receptors and their ligands has been widely reported. Active Notch signal inhibits the differentiation of HSCs while promotes their expansion, suggesting that ex vivo expansion of hematopoietic progenitor cells could be enhanced by manipulating Notch signal pathways. In this article the Notch signal pathways, Notch signal and maintenance of hematopoietic progenitor cells, Notch signal and expansion of hematopoietic progenitor cells and molecular mechanism of Notch signal maintaining undifferentiation of hematopoietic progenitor cells were reviewed.
造血祖细胞（HPCs）的体外扩增对于临床应用具有重要价值，然而，传统的体外培养会对长期造血重建能力产生负面影响。在造血系统中，Notch受体及其配体的表达已被广泛报道。激活的Notch信号抑制造血干细胞的分化，同时促进其扩增，这表明通过调控Notch信号通路可以增强造血祖细胞的体外扩增。本文对Notch信号通路、Notch信号与造血祖细胞的维持、Notch信号与造血祖细胞的扩增以及Notch信号维持造血祖细胞未分化状态的分子机制进行了综述。
