Martín de Carpi J, Vilar Escrigas P, Varea Calderón V
Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, España.
An Pediatr (Barc). 2008 Oct;69(4):351-4. doi: 10.1157/13126560.
Paediatric ulcerative colitis tends to be more severe and more extensive than in adults. Steroid-resistance is also more frequent, producing a high colectomy rate in these patients. Cyclosporine A has showed to be an effective rescue therapy in acute attacks, avoiding colectomy. However, the long-term benefits are less promising and there is also very serious toxicity associated with its use. Therefore, novel effective therapies in paediatric ulcerative colitis are mandatory. We present a patient with a severe attack of steroid-resistant ulcerative-colitis in whom infliximab has proved effective in inducing a maintained remission and in avoiding the need for colectomy.
小儿溃疡性结肠炎往往比成人更严重、范围更广。激素抵抗也更常见,导致这些患者的结肠切除率很高。环孢素A已被证明是急性发作时有效的挽救疗法,可避免结肠切除。然而,其长期益处不太乐观,且使用时还存在非常严重的毒性。因此,小儿溃疡性结肠炎需要新的有效疗法。我们报告一例严重的激素抵抗性溃疡性结肠炎发作患者,英夫利昔单抗已被证明对诱导持续缓解和避免结肠切除有效。