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[在氯化钠刺激下米托蒽醌和氨甲蒽醌与聚（d（G-C））在B-Z转变中的结合]

[Binding of mitoxantrone and ametantrone with poly(d(G-C)) on the B---Z transition, stimulated by NaCl].

作者信息

Babaian Iu S, Manzinii D, Ksodo L E

出版信息

Biofizika. 1991 Mar-Apr;36(2):266-70.

PMID:1892903
Abstract

Binding of antitumoral preparations mitoxantrone and ametantrone with right and left helical DNA was investigated. B-Z conformational transition stimulated by NaCl in the molecules of poly[d(G.C)].poly[d(G-C)] in complex with mitoxantrone and ametantrone was studied by the method of circular dichroism. It was shown that these compounds disturb B-Z transition but do not inhibit it.

摘要

研究了抗肿瘤制剂米托蒽醌和氨茴蒽醌与左右螺旋DNA的结合。采用圆二色性方法研究了聚[d(G.C)].聚[d(G-C)]分子与米托蒽醌和氨茴蒽醌复合物中NaCl刺激的B-Z构象转变。结果表明，这些化合物干扰但不抑制B-Z转变。

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Biofizika. 1991 Mar-Apr;36(2):266-70.
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