[通过圆二色光谱变化分析研究抗肿瘤药物米托蒽醌和氨甲蒽醌与DNA的相互作用]
[The study of the interaction of antineoplastic drugs mitoxantrone and ametantrone with DNA using the analysis of changes in circular dichroism spectra].
作者信息
Babaian Iu S, Sngrian A E, Kazarian R S, Avetisian M G, Sogomonian L R, Garibian D V
机构信息
Yerevan State University, Armenia.
出版信息
Biofizika. 1998 May-Jun;43(3):422-6.
The influence of the ionic strength and temperature of medium on the changes in the geometry of the double stranded DNA of different nucleotide content upon the formation of complexes with antitumor drugs mitoxantrone and ametantrone was investigated. It is shown that from circular dichroism spectra it is possible to determine the relative intensity of changes in the geometry of DNA double helix upon binding with the drugs investigated. The binding of one ametantrone molecule causes greater changes in the geometry of DNA double helix than the binding of mitoxantrone.
研究了介质的离子强度和温度对不同核苷酸含量的双链DNA与抗肿瘤药物米托蒽醌和氨甲蒽醌形成复合物时其几何结构变化的影响。结果表明，从圆二色光谱可以确定DNA双螺旋与所研究药物结合时其几何结构变化的相对强度。一个氨甲蒽醌分子的结合比米托蒽醌的结合引起DNA双螺旋几何结构更大的变化。
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