刺激多巴胺能系统的药物对大鼠纹状体磷酸二酯酶活性的影响。
Effect of drugs stimulating dopaminergic system on phosphodiesterase activity in rat striatum.
作者信息
Janiec W, Piekarska T, Szczypior M, Misterkiewicz E
出版信息
Pol J Pharmacol Pharm. 1976 Nov-Dec;28(6):631-4.
PMID:189292
Abstract
Two forms of phosphodiesterase exist in the rat striatum, one with high (PDE -- I), and one with low (PDE -- II) affinity to substrate (cyclic 3',5'-AMP). The results obtained suggest that inhibition of PDE -- I activity by apomorphine or amantadine is partially related to their stimulating effect on dopaminergic system in the striatum.
摘要
大鼠纹状体中存在两种形式的磷酸二酯酶，一种对底物（环3',5'-腺苷一磷酸）具有高亲和力（PDE - I），另一种具有低亲和力（PDE - II）。所得结果表明，阿扑吗啡或金刚烷胺对PDE - I活性的抑制作用部分与其对纹状体中多巴胺能系统的刺激作用有关。
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