Wang Zong-Chun, Xu Xiao-Ding, Chen Chang-Sheng, Wang Gan-Rui, Wang Bo, Zhang Xian-Zheng, Zhuo Ren-Xi
Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Colloids Surf B Biointerfaces. 2008 Dec 1;67(2):245-52. doi: 10.1016/j.colsurfb.2008.09.002. Epub 2008 Sep 11.
A series of novel hydrogels based on poly(N-isopropylacrylamide) (PNIPAAm) with pendant poly(N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, resulting hydrogels presented favorable pH sensitivity as well as improved thermosensitive properties, including enlarged water containing capability at room temperature and faster shrinking/swelling rate upon heating. In addition, fish DNA, used as a model drug, was loaded into the hydrogels, and the controlled release behavior of the drug-loaded hydrogels at different temperatures (22 and 37 degrees C) was further studied.
设计并合成了一系列基于聚（N-异丙基丙烯酰胺）（PNIPAAm）且带有聚（N-（2-（二甲氨基）乙基）-甲基丙烯酰胺）（PDMAEMA）接枝侧链的新型水凝胶。通过扫描电子显微镜（SEM）观察形态、差示扫描量热法（DSC）表征热性能以及研究外部温度变化时的收缩/溶胀动力学，考察了PDMAEMA接枝侧链对所得水凝胶性能的影响。与传统的PNIPAAm水凝胶相比，所得水凝胶具有良好的pH敏感性以及改善的热敏性能，包括在室温下具有更大的含水量以及加热时更快的收缩/溶胀速率。此外，将鱼DNA用作模型药物载入水凝胶中，并进一步研究了载药水凝胶在不同温度（22和37摄氏度）下的控释行为。
