用于癌症治疗的刺激响应性聚合物系统

Alsuraifi Ali, Curtis Anthony, Lamprou Dimitrios A, Hoskins Clare

Institute of Science and Technology in Medicine, Keele University, Keele ST5 5BG, UK.

College of Dentistry, University of Basrah, Basrah 61004, Iraq.

Pharmaceutics. 2018 Aug 22;10(3):136. doi: 10.3390/pharmaceutics10030136.

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature have led to a major boom in research focus. This review article concentrates on the use of these smart polymers in cancer therapy. Nanotechnologies have shown potential as drug carriers leading to increased drug efficacy and penetration. Multifunctional smart carriers which can release their payload upon an external or internal trigger such as pH or temperature are proving to be major frontrunners in the development of effective strategies to overcome this disease with minimal patient side effects.

纳米级聚合物系统主导了药物递送进展的革命。它们在抗癌斗争中的潜力是其他技术无法比拟的。它们的功能增强、靶向能力和刺激响应特性导致了研究重点的大幅增长。这篇综述文章专注于这些智能聚合物在癌症治疗中的应用。纳米技术已显示出作为药物载体的潜力，可提高药物疗效和渗透性。能够在外部或内部触发因素（如pH值或温度）作用下释放其负载的多功能智能载体，正成为开发有效策略以最小化患者副作用来攻克这种疾病的主要领跑者。