Weltzin T E, McConaha C, McKee M, Hsu L K, Perel J, Kaye W H
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA 15212.
Biol Psychiatry. 1991 Jul 1;30(1):37-48. doi: 10.1016/0006-3223(91)90068-w.
Women who are of normal weight and have bulimia nervosa exhibit multiple neuroendocrine disturbances. We hypothesized that bingeing and vomiting behavior could be contributory because food consumption in healthy volunteers increases plasma cortisol and prolactin secretion and suppresses growth hormone secretion. Thus, we investigated the effects of bingeing and vomiting on the circadian pattern (measurements every 20 min for 24 hr) of these hormones in comparison to healthy control women eating normally. Bingeing and vomiting were associated with modest increases in cortisol and prolactin and reductions in growth hormone secretion. However, this bingeing or purging did not alter mean 24-hr pattern of cortisol and growth hormone secretion as values for bulimics were similar to controls. While mean daytime patterns of prolactin secretion were similar in bulimics and controls, bulimic patients had a significant reduction of nocturnal prolactin levels. In summary, bingeing and vomiting does not appear to have a substantial influence on hormonal secretion. However, bulimic women have blunted nocturnal prolactin patterns.
体重正常且患有神经性贪食症的女性存在多种神经内分泌紊乱。我们推测，暴饮暴食和呕吐行为可能是导致这些紊乱的原因，因为健康志愿者进食会增加血浆皮质醇和催乳素分泌，并抑制生长激素分泌。因此，我们研究了暴饮暴食和呕吐对这些激素昼夜节律模式（每20分钟测量一次，持续24小时）的影响，并与正常饮食的健康对照女性进行比较。暴饮暴食和呕吐与皮质醇和催乳素适度增加以及生长激素分泌减少有关。然而，这种暴饮暴食或催吐并未改变皮质醇和生长激素分泌的24小时平均模式，因为贪食症患者的值与对照组相似。虽然贪食症患者和对照组白天催乳素分泌的平均模式相似，但贪食症患者夜间催乳素水平显著降低。总之，暴饮暴食和呕吐似乎对激素分泌没有实质性影响。然而，患有贪食症的女性夜间催乳素模式较为迟钝。
