Romo-Nava Francisco, Guerdjikova Anna I, Mori Nicole N, Scheer Frank A J L, Burgess Helen J, McNamara Robert K, Welge Jeffrey A, Grilo Carlos M, McElroy Susan L
Lindner Center of HOPE, Mason, OH, United States.
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Front Nutr. 2022 Sep 8;9:978412. doi: 10.3389/fnut.2022.978412. eCollection 2022.
Emerging research suggests that food intake timing, eating behavior and food preference are associated with aspects of the circadian system function but the role that the circadian system may play in binge eating (BE) behavior in humans remains unclear.
To systematically evaluate the evidence for circadian system involvement in BE behavior.
Systematic searches of PubMed, EMBASE, and Scopus were performed for reports published from inception until May 2020 (PROSPERO Registration CRD42020186325). Searches were conducted by combining Medical Subject Headings related to the circadian system, BE behavior, and/or interventions. Observational and interventional studies in humans with BE behavior published in peer-review journals in the English language were included. Studies were assessed using quality and risk of bias tools (AXIS, ROB 2.0, or ROBINS).
The search produced 660 articles, 51 of which were included in this review. Of these articles, 46 were observational studies and 5 were interventional trials. Evidence from these studies suggests that individuals with BE behavior tend to have more food intake, more binge cravings, and more BE episodes later in the day. Hormonal and day/night locomotor activity rhythm disturbances may be associated with BE behavior. Furthermore, late diurnal preference ("eveningness") was associated with BE behavior and chronobiological interventions that shift the circadian clock earlier (e.g., morning bright light therapy) were found to possibly decrease BE behavior. Substantive clinical overlap exists between BE and night eating behavior. However, there is a significant knowledge gap regarding their potential relationship with the circadian system. Limitations include the lack of studies that use best-established techniques to assess the chronobiology of BE behavior, heterogeneity of participants, diagnostic criteria, and study design, which preclude a meta-analytic approach.
Current evidence, although limited, suggests that the circadian system may play a role in the etiology of BE behavior. Further mechanistic studies are needed to fully characterize a potential role of the circadian system in BE behavior. A chronobiological approach to studying BE behavior may lead to identification of its neurobiological components and development of novel therapeutic interventions.
[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020186325], identifier [CRD42020186325].
新出现的研究表明，食物摄入时间、进食行为和食物偏好与昼夜节律系统功能的各个方面有关，但昼夜节律系统在人类暴饮暴食（BE）行为中可能发挥的作用仍不清楚。
系统评价昼夜节律系统参与BE行为的证据。
对PubMed、EMBASE和Scopus进行系统检索，查找从创刊至2020年5月发表的报告（PROSPERO注册号CRD42020186325）。通过结合与昼夜节律系统、BE行为和/或干预措施相关的医学主题词进行检索。纳入在同行评审期刊上发表的关于有BE行为的人类的观察性和干预性研究，语言为英语。使用质量和偏倚风险工具（AXIS、ROB 2.0或ROBINS）对研究进行评估。
检索共得到660篇文章，其中51篇纳入本综述。在这些文章中，46篇为观察性研究，5篇为干预性试验。这些研究的证据表明，有BE行为的个体往往在一天中较晚的时候有更多的食物摄入量、更多的暴饮暴食欲望和更多的BE发作。激素和昼夜运动活动节律紊乱可能与BE行为有关。此外，昼夜偏好较晚（“夜型”）与BE行为有关，并且发现将生物钟提前的时间生物学干预措施（如早晨强光疗法）可能会减少BE行为。BE与夜间进食行为之间存在实质性的临床重叠。然而，关于它们与昼夜节律系统的潜在关系存在重大知识空白。局限性包括缺乏使用最成熟技术评估BE行为时间生物学的研究、参与者的异质性、诊断标准和研究设计，这使得无法采用荟萃分析方法。
目前的证据虽然有限，但表明昼夜节律系统可能在BE行为的病因学中起作用。需要进一步的机制研究来全面描述昼夜节律系统在BE行为中的潜在作用。采用时间生物学方法研究BE行为可能会导致确定其神经生物学成分并开发新的治疗干预措施。
[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020186325]，标识符[CRD42020186325]。
