Fu Xin, Ji Rong, Dam Jorgen
Department of Women's and Children's Health, Obstetrics and Gynecology, Uppsala University, SE-75185 Uppsala, Sweden.
Regul Toxicol Pharmacol. 2009 Feb;53(1):1-5. doi: 10.1016/j.yrtph.2008.09.003. Epub 2008 Oct 1.
In the present study, the acute, subacute and genetic toxicity of Coenzyme Q10 (CoQ10) in the form of Bio-Quinone (Pharma Nord, Denmark) was assessed. LD(50) of CoQ10 by oral treatment was greater than 20g/kg body weight in both female and male mice. Genotoxicity was assessed in mice by Ames test in Salmonella typhimurium strains TA97, TA98, TA100 and TA102, by bone marrow micronucleus test and sperm abnormality. Thirty-day subacute toxicity was conducted with oral daily dose at 0, 0.56, 1.13 and 2.25g/kg body weight in rats. No significant changes in body weight, food intake, behavior, mortality, hematology, blood biochemistry, vital organ weight, sperm abnormality, mutagenicity and micronucleus formation were observed and no clinical signs or adverse effects were detected by administration of CoQ10. These results support the safety of CoQ10 for oral consumption.
在本研究中，评估了丹麦法玛诺德公司生产的生物醌形式的辅酶Q10（CoQ10）的急性、亚急性和遗传毒性。口服给予CoQ10时，雌性和雄性小鼠的半数致死量（LD50）均大于20克/千克体重。通过对鼠伤寒沙门氏菌TA97、TA98、TA100和TA102菌株进行Ames试验、骨髓微核试验和精子畸形试验，评估了CoQ10对小鼠的遗传毒性。以0、0.56、1.13和2.25克/千克体重的每日口服剂量对大鼠进行了为期30天的亚急性毒性试验。未观察到体重、食物摄入量、行为、死亡率、血液学、血液生物化学、重要器官重量、精子畸形、致突变性和微核形成有显著变化，且给予CoQ10后未检测到临床症状或不良反应。这些结果支持了口服CoQ10的安全性。
