Ortega G, Molina Boix M, de Paco M, Sáez J A, Cuesta F, Agudo M D
Servicio de Medicina Interna, Hospital Virgen de la Arrixaca, El Palmar, Murcia.
An Med Interna. 1991 Feb;8(2):74-8.
The efficacy and tolerance of captopril was prospectively studied as monotherapy for blood hypertension (BH), as well as combined modality with thiazides diuretic and nifedipine as a third drug. 95 cases of BH were followed up for a period of 6 months. 43.15% of the patients who received monotherapy with captopril were controlled (diastolic BP less than 95 mmHg). Those patients who had a diuretic added showed a response of 71.75% and those administered 3 drugs showed a response of 81.25%. The decrease of BH was significant in all groups (p less than 0.01). There was a significant correlation (p less than 0.01) between the response to monotherapy and severity of BH (mild BH 67.50% and severe BH 35.20%). 6.5% of patients abandoned the treatment because of secondary effects. No alterations were noted in the blood test. Monotherapy with captopril is effective in control of mild and moderate BH. In resistant patients, the addition of a diuretic and nifedipine retard as a third drug is useful and well-tolerated in any type of BH severity.
对卡托普利作为高血压（BH）单一疗法以及与噻嗪类利尿剂联合使用并加用硝苯地平作为第三种药物的疗效和耐受性进行了前瞻性研究。对95例BH患者进行了为期6个月的随访。接受卡托普利单一疗法的患者中有43.15%得到控制（舒张压低于95 mmHg）。加用利尿剂的患者有效率为71.75%，使用三种药物的患者有效率为81.25%。所有组的血压下降均显著（p<0.01）。单一疗法的疗效与BH严重程度之间存在显著相关性（p<0.01）（轻度BH为67.50%，重度BH为35.20%）。6.5%的患者因副作用而放弃治疗。血液检查未发现异常。卡托普利单一疗法对控制轻度和中度BH有效。对于难治性患者，加用利尿剂和硝苯地平作为第三种药物在任何类型的BH严重程度中均有效且耐受性良好。
