Alcántara Nicolás J, Cano Cano R, Cano Cano E, Contreras C, García Galvis J A, García Giralda L, González Comeche J, Madrid Conesa A, Ramos La Torre F, Sánchez Moreno J
GRAMU, Unidad de Hipertensión Hospitalaria, Murcia.
Rev Clin Esp. 1990 Mar;186(5):201-5.
The effect of single dose (50 mg) Captopril (C) used either alone or associated to diuretics (50 mg hydrochlorothiazide -HCTI) in the treatment of mild-moderate essential arterial hypertension was studied in a multicentric study. Eighty eight patients were chosen. After a minimum of 4 month follow-up period 53.4% responded (BDP less than 95 mm Hg) to single dose C (group 1:47 patients), 89.77% to 50 mg C in single dose together with 50 mg HTIT (group 2: 32 patients), 95.45% of two 50 mg doses of C and 50 mg HCIT (group 3: 5 patients), and 97.72% responded to 3 doses of C and 50 mg of HCTI (group 4: 2 patients). The decrease in blood pressure values was statistically significant (p, 000, Wilcoxon test) in groups 1 and 2, having a mean decrease in blood pressure (BP) of 14%. In group 1 (n = 42) the SBP which initially was 165.72 +/- 11.32, decreased to 148.28 +/- 11.5 and the DBP decreased from 101.55 +/- 5.68 to 87.28 +/- 6.59. In group 2 (n = 32) the SBP decreased from 173.50 +/- 14.08 to 152.44 +/- 20.8 and the DBP from 103.34 +/- 5.29 to 87.47 +/- 6.39. The response to monotherapy could not be statistically correlated either to early essential hypertension or to the patients age. Treatment was discontinued in three cases due to the secondary effects, cough, ageusia and nervousness, showing the remaining patients a good tolerance. No changes were observed in the analytical parameters. This study shows the usefulness and tolerance of single dose C as the initial treatment of mild to moderate essential hypertension.
在一项多中心研究中，研究了单剂量（50毫克）卡托普利（C）单独使用或与利尿剂（50毫克氢氯噻嗪-HCTI）联合使用治疗轻度至中度原发性动脉高血压的效果。选取了88例患者。经过至少4个月的随访期后，单剂量C组（第1组：47例患者）中53.4%有反应（舒张压低于95毫米汞柱），单剂量50毫克C与50毫克HCTI联合组（第2组：32例患者）中89.77%有反应，两剂50毫克C与50毫克HCTI联合组（第3组：5例患者）中95.45%有反应，三剂C与50毫克HCTI联合组（第4组：2例患者）中97.72%有反应。第1组和第2组血压值的下降具有统计学意义（p<0.000，威尔科克森检验），平均血压下降14%。在第1组（n = 42）中，初始收缩压为165.72±11.32，降至148.28±11.5，舒张压从101.55±5.68降至87.28±6.59。在第2组（n = 32）中，收缩压从173.50±14.08降至152.44±20.8，舒张压从103.34±5.29降至87.47±6.39。单药治疗的反应与早期原发性高血压或患者年龄均无统计学相关性。3例因副作用（咳嗽、味觉丧失和紧张）而停药，其余患者耐受性良好。分析参数未观察到变化。本研究表明单剂量C作为轻度至中度原发性高血压初始治疗的有效性和耐受性。
