Caserta Maria T, Ragin Ann, Hermida Adriana P, Ahrens R John, Wise Leon
Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA.
Psychiatry Res. 2008 Nov 30;164(2):154-9. doi: 10.1016/j.pscychresns.2008.04.002. Epub 2008 Oct 19.
In this study, we use magnetic resonance spectroscopy (MRS) at 3 Tesla to measure N-acetyl aspartate (NAA), myo-inositol (mI) and choline (Cho) to creatine (Cr) ratios in R (right) and L (left) hippocampi (H) in 8 mildly memory impaired (MMI), 6 probable Alzheimer's Disease (PRAD), and 17 control subjects. NAA/Cr was significantly reduced in the RH in the MMI group and bilaterally in the PRAD group vs. controls. No other metabolite differences were noted between the three groups. Five MMI subjects have converted to PRAD in follow-up. These findings suggest that RH NAA/Cr ratios measured at 3 Tesla may be a sensitive marker of future progression to dementia in a clinically defined population with isolated memory complaints.
在本研究中，我们使用3特斯拉的磁共振波谱（MRS）来测量8名轻度记忆障碍（MMI）患者、6名可能患有阿尔茨海默病（PRAD）患者以及17名对照受试者右侧（R）和左侧（L）海马体（H）中N-乙酰天门冬氨酸（NAA）、肌醇（mI）、胆碱（Cho）与肌酸（Cr）的比值。与对照组相比，MMI组右侧海马体以及PRAD组双侧海马体中的NAA/Cr显著降低。三组之间未发现其他代谢物差异。随访中有5名MMI受试者已转变为PRAD。这些发现表明，在3特斯拉下测量的右侧海马体NAA/Cr比值可能是临床上仅表现为记忆障碍的特定人群未来进展为痴呆的敏感标志物。
