Francis R B
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Blood Coagul Fibrinolysis. 1991 Apr;2(2):341-53. doi: 10.1097/00001721-199104000-00018.
Recent evidence suggests that sickle cell disease (SCD) can be considered a hypercoagulable state, in which both platelet activation and thrombin generation are abnormally increased. Although thrombosis is now known to play an important role in at least one of the vasocclusive complications of SCD, namely stroke, the significance of hypercoagulability in the pathogenesis of vascular occlusion in SCD remains unclear. This review summarizes current evidence regarding platelet, coagulation, and fibrinolytic abnormalities in SCD and their possible role in vascular occlusion. Potential implications for therapy are also discussed.
最近的证据表明，镰状细胞病（SCD）可被视为一种高凝状态，其中血小板活化和凝血酶生成均异常增加。尽管现在已知血栓形成在SCD的至少一种血管闭塞性并发症（即中风）中起重要作用，但高凝状态在SCD血管闭塞发病机制中的意义仍不清楚。本综述总结了目前关于SCD中血小板、凝血和纤溶异常及其在血管闭塞中可能作用的证据。还讨论了对治疗的潜在影响。
