Zia Khalid Mahmood, Zuber Mohammad, Bhatti Ijaz Ahmad, Barikani Mehdi, Sheikh Munir Ahmad
Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan.
Int J Biol Macromol. 2009 Jan 1;44(1):18-22. doi: 10.1016/j.ijbiomac.2008.09.011. Epub 2008 Sep 30.
Chitin based polyurethane elastomers with potential as biomedical implants with tunable mechanical properties were synthesized by step growth polymerization techniques using poly(epsilon-caprolactone) (PCL) and 4,4'-diphenylmethane diisocyanate (MDI). The prepolymer was extended with different mass ratios of chitin and 1,4-butane diol (BDO). Molecular characterization was done using FTIR, 1H NMR and 13C NMR techniques. The mechanical properties of these polymers were improved with increase in the chitin contents. Optimum mechanical properties were obtained from elastomers extended with chitin in comparison to elastomers extended with BDO. Cytotoxicity of the synthesized polyurethane samples was affected by varying the chitin contents in the chemical composition of the final polyurethane (PU). It is revealed that the final polymers extended with chitin are preferred candidates for surgical threads with on going investigations into their in vitro biocompatibility and non-toxicity.
采用逐步增长聚合技术，以聚己内酯（PCL）和4,4'-二苯基甲烷二异氰酸酯（MDI）合成了具有潜在应用价值、机械性能可调的基于几丁质的聚氨酯弹性体。预聚物用不同质量比的几丁质和1,4-丁二醇（BDO）进行扩链。使用傅里叶变换红外光谱（FTIR）、核磁共振氢谱（1H NMR）和核磁共振碳谱（13C NMR）技术进行分子表征。这些聚合物的机械性能随着几丁质含量的增加而提高。与用BDO扩链的弹性体相比，用几丁质扩链的弹性体具有最佳的机械性能。合成的聚氨酯样品的细胞毒性受最终聚氨酯（PU）化学成分中几丁质含量变化的影响。结果表明，用几丁质扩链的最终聚合物是手术缝线的优选候选材料，目前正在对其体外生物相容性和无毒性进行研究。
