Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
Int J Biol Macromol. 2011 Dec 1;49(5):1131-6. doi: 10.1016/j.ijbiomac.2011.09.010. Epub 2011 Sep 16.
Chitin based polyurethane bio-nanocomposites (PUBNC) were prepared using chitin, Delite HPS bentonite nanoclay enriched in montmorillonite (MMT), 4,4'-diphenylmethane diisocyanate (MDI) and polycaprolactone polyol CAPA 231 (3000 g/mol(-1)). The prepolymers having different concentration of Delite HPS bentonite nanoclay were extended with 2 moles of chitin. The structures of the resulted polymers were determined by FT-IR technique. The effect of nanoclay contents on mechanical properties and in vitro biocompatibility was investigated. The mechanical properties of the synthesized materials were improved with increase in the Delite HPS bentonite nanoclay contents. Optimum mechanical properties were obtained from the PU bio-nanocomposite samples having 4% Delite HPS bentonite nanoclay. The results revealed that the final PU bio-nanocomposite having 2% Delite HPS bentonite nanoclay contents is ideal contenders for surgical threads with on going investigations into their in vitro biocompatibility, non-toxicity, and mechanical properties.
壳聚糖基聚氨酯生物纳米复合材料（PUBNC）是使用壳聚糖、富含蒙脱石的 Delite HPS 膨润土纳米粘土（MMT）、4,4'-二苯基甲烷二异氰酸酯（MDI）和聚己内酯多元醇 CAPA 231（3000 g/mol(-1)）制备的。将具有不同 Delite HPS 膨润土纳米粘土浓度的预聚物用 2 摩尔壳聚糖进行扩链。通过傅里叶变换红外（FT-IR）技术确定了所得聚合物的结构。研究了纳米粘土含量对机械性能和体外生物相容性的影响。随着 Delite HPS 膨润土纳米粘土含量的增加，合成材料的机械性能得到了提高。从含有 4% Delite HPS 膨润土纳米粘土的 PU 生物纳米复合材料样品中获得了最佳的机械性能。结果表明，最终含有 2% Delite HPS 膨润土纳米粘土含量的 PU 生物纳米复合材料是手术缝线的理想候选材料，正在对其体外生物相容性、非毒性和机械性能进行研究。
