Sales V, Rojo J, Collazo J, Lagunas E, Aguilar E, Albisua L
Clinical Epidemiology Unit, General Hospital of Mexico, Ministry of Health- School of Medicine, National Autonomous University of Mexico, Mexico City.
In Vivo. 1991 May-Jun;5(3):281-5.
Thirty-nine patients with chronic granulocytic leukemia (CGL) in blastic crisis (BC) were studied from 1981 to 1988 at the Hematology Service of the General Hospital of Mexico. The patients were from 18 to 80 years old. Twenty-one patients (54%) were in lymphatic BC and 18 patients (46%) corresponded to BC myeloid. All the patients were treated with different chemotherapy schedules. Only three patients in lymphoid BC and two in myeloid BC achieved complete remission. The longest remission time was 24 weeks and the longest survival 36 weeks. The clinical and laboratory features, such as age, anemia, bleeding, fever, bone pain, adenopathy, splenomegaly, hepatomegaly, extramedullary infiltration, leukocyte count, hemoglobin, platelets, blast cells, in peripheral blood and bone marrow, basophils, and morphology and cytochemistry stains characteristic in bone marrow, were compared between the two groups of patients. None of the clinical and laboratory findings studied were significantly different between the two types of BC, except the evolution time from the diagnosis to the BC, which was more than than two years for most of the patients in lymphoid BC. We also studied the prognosis factors related to survival time. There were no clinical or laboratory differences among the patients who survived more than or less than 14 weeks.(ABSTRACT TRUNCATED AT 250 WORDS)
1981年至1988年期间，墨西哥总医院血液科对39例处于急变期（BC）的慢性粒细胞白血病（CGL）患者进行了研究。患者年龄在18岁至80岁之间。21例患者（54%）处于淋巴细胞急变期，18例患者（46%）为髓细胞急变期。所有患者均接受了不同的化疗方案。只有3例淋巴细胞急变期患者和2例髓细胞急变期患者实现了完全缓解。最长缓解时间为24周，最长生存期为36周。比较了两组患者的临床和实验室特征，如年龄、贫血、出血、发热、骨痛、腺病、脾肿大、肝肿大、髓外浸润、外周血和骨髓中的白细胞计数、血红蛋白、血小板、原始细胞、嗜碱性粒细胞，以及骨髓中的形态学和细胞化学染色特征。除了从诊断到急变期的演变时间外，所研究的临床和实验室检查结果在两种类型的急变期之间均无显著差异，大多数淋巴细胞急变期患者的演变时间超过两年。我们还研究了与生存时间相关的预后因素。存活时间超过或少于14周的患者在临床或实验室方面没有差异。（摘要截选至250字）
