Blazek C, Megahed M
Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland.
Hautarzt. 2008 Nov;59(11):874-7. doi: 10.1007/s00105-008-1650-8.
Lichen planopilaris (LPP) is an inflammatory condition of unknown etiology that affects pilosebaceous units, mainly of the scalp, and results in scaring alopecia.
A 51-year-old male presented with a pruritic eruption on the cheek consisting of atrophic macules and erythematous folliculocentric papules.
Biopsy revealed a perifollicular lymphocytic infiltrate and vacuolar degeneration of the dermoepidermal junction consistent with LPP. Many treatment modalities have been utilized, with varying degrees of success. Our patient responded poorly to topical steroids. After nine months of topical tacrolimus therapy, his lesions resolved entirely.
The treatment of our patient demonstrates tacrolimus as a novel topical therapeutic option for patients with LPP.
扁平苔藓样毛发角化病（LPP）是一种病因不明的炎症性疾病，主要影响头皮的毛囊皮脂腺单位，导致瘢痕性脱发。
一名51岁男性患者面颊出现瘙痒性皮疹，由萎缩性斑疹和以毛囊为中心的红斑丘疹组成。
活检显示毛囊周围淋巴细胞浸润及真皮表皮交界处空泡变性，符合扁平苔藓样毛发角化病。已采用多种治疗方法，疗效各异。我们的患者对局部类固醇治疗反应不佳。局部使用他克莫司治疗九个月后，他的皮损完全消退。
对我们患者的治疗表明，他克莫司是扁平苔藓样毛发角化病患者一种新的局部治疗选择。
