成纤维细胞生长因子诱导培养的脑桥被盖胆碱能神经元存活率增加。

Fibroblast growth factor-induced increased survival of cholinergic mesopontine neurons in culture.

作者信息

Garcia-Rill E, Davies D L, Skinner R D, Biedermann J A, McHalffey C

机构信息

Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205.

出版信息

Brain Res Dev Brain Res. 1991 Jun 21;60(2):267-70. doi: 10.1016/0165-3806(91)90056-o.

DOI:10.1016/0165-3806(91)90056-o

PMID:1893568

Abstract

Basic fibroblast growth factor (bFGF) was found to increase the survival of immunocytochemically-identified cholinergic mesopontine neurons in dissociated cell cultures of embryonic rat midbrain. In contrast, cultures exposed to, (a) bFGF and an antibody to bFGF, (b) antibody to bFGF alone, or (c) untreated, contained approximately half the number of cholinergic neurons compared to bFGF-treated cultures.

摘要

研究发现，碱性成纤维细胞生长因子（bFGF）可提高胚胎大鼠中脑解离细胞培养物中免疫细胞化学鉴定的脑桥胆碱能神经元的存活率。相比之下，与用bFGF处理的培养物相比，暴露于以下情况的培养物中胆碱能神经元数量约为其一半：（a）bFGF和bFGF抗体；（b）单独的bFGF抗体；或（c）未处理的培养物。