Zhang Pin, Di Jian-Zhong, Zhu Zhong-Zheng, Wu Hui-Min, Wang Yu, Zhu Guanshan, Zheng Qi, Hou Lifang
Department of General Surgery, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
Jpn J Clin Oncol. 2008 Dec;38(12):861-6. doi: 10.1093/jjco/hyn111. Epub 2008 Oct 19.
Transforming growth factor-beta 1 (TGF-beta1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-beta1 polymorphisms on gastric cancer risk, we studied the association between C-509T and T+29C (Leu10Pro) polymorphisms in TGF-beta1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the -509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36-0.90) and a 0.58-fold (95% CI = 0.36-0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-beta1-509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.
转化生长因子-β1（TGF-β1）在癌症早期抑制肿瘤增殖，而在癌症后期促进肿瘤生长和转移。为了研究TGF-β1基因多态性对胃癌风险的影响，我们在中国人群的414例病例和414例对照中研究了TGF-β1基因中C-509T和T+29C（Leu10Pro）多态性与胃癌风险之间的关联。当将总体胃癌病例与对照进行比较时，在所检测的两种多态性的基因型分布中未发现显著差异。然而，按肿瘤分期分层时，与非携带者相比，-509T和+29C等位基因携带者患TNM I+II期胃癌的风险分别降低了0.57倍（95%CI = 0.36-0.90）和0.58倍（95%CI = 0.36-0.91）。我们得出结论，TGF-β1 -509T和+29C等位基因可能在I+II期胃癌的发生中具有保护作用。
