Gu You-You, Wang Huan, Wang Su
Department of Endocrinology, The Fifth Central Hospital of Tianjin China.
Community Health Service Center of Hu Jiayuan StreetBinhai New District, Tianjin, China; Graduate School of Tianjin Medical UniversityChina.
Int J Clin Exp Med. 2015 Oct 15;8(10):17932-40. eCollection 2015.
Objective The association between polymorphism of TGF-β1 and cancer risk has been discussed. Method A comprehensive electronic search was performed to identify articles published up until 12 December 2014 in Medline and Embase databases. The statistical analysis was performed by STATA 11.0 software and Review Manager 5.1 software.
In the present meta analysis, for C-509T (31 studies, 12944 cases and 15530 controls), no significant cancer risk was found in the overall analysis. In subgroup analysis, C-509T polymorphism was associated with decreased cancer risk in Asian population (OR=0.73 and 95% CI=0.59-0.90 for CT vs. CC), and there were no significant risks in gastric cancer, breast cancer, and other cancers. For T869C (11 studies, 2730 cases and 2973 controls), significantly increased risks of cancer were observed, and the ORs (95% CI) were 1.81 (1.18-2.78) for CC vs. TT, 1.50 (1.07-2.09) for TC vs. TT, 1.61 (1.13-2.30) for TC+CC vs. TT and 1.38 (1.11-1.73) for C-allele vs. T-allele, respectively. Subgroup analyses stratified by ethnicity and types of cancer were also performed, and the results indicated that T869C polymorphism was associated with cancer risk in Caucasion [1.93 (1.52-2.46) for TC vs. TT], but not in Asian [1.23 (0.80-1.90) for TC vs. TT]. We also observed that the T869C was associated with increased risk of squamous cell cancer of head and neck (SCCHN) [1.34 (1.07-1.67) for TC vs. TT]. Conclusion Decreased cancer risk association was observed in Asian for C-509T and significantly increased risk of cancer was observed for T869C.
目的 探讨转化生长因子-β1（TGF-β1）基因多态性与癌症风险之间的关联。方法 进行全面的电子检索，以识别截至2014年12月12日在Medline和Embase数据库中发表的文章。采用STATA 11.0软件和Review Manager 5.1软件进行统计分析。
在本次荟萃分析中，对于C-509T（31项研究，12944例病例和15530例对照），总体分析未发现显著的癌症风险。亚组分析中，C-509T基因多态性与亚洲人群癌症风险降低相关（CT与CC相比，OR = 0.73，95%CI = 0.59 - 0.90），在胃癌、乳腺癌和其他癌症中无显著风险。对于T869C（11项研究，2730例病例和2973例对照），观察到癌症风险显著增加，CC与TT相比的OR（95%CI）为1.81（1.18 - 2.78），TC与TT相比为1.50（1.07 - 2.09），TC + CC与TT相比为1.61（1.13 - 2.30），C等位基因与T等位基因相比为1.38（1.11 - 1.73）。还按种族和癌症类型进行了亚组分析，结果表明T869C基因多态性与白种人癌症风险相关（TC与TT相比为1.93（1.52 - 2.46）），但与亚洲人无关（TC与TT相比为1.23（0.80 - 1.90））。我们还观察到T869C与头颈部鳞状细胞癌（SCCHN）风险增加相关（TC与TT相比为1.34（1.07 - 1.67））。结论 在亚洲人群中观察到C-509T与癌症风险降低相关，而T869C与癌症风险显著增加相关。
