Srivastava R K, Sridaran R
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310-1495.
Contraception. 1991 Aug;44(2):209-16. doi: 10.1016/0010-7824(91)90120-5.
Effects of a potent third generation LHRH antagonist [Nal-Lys antagonist:antide] have been observed during the first half of pregnancy in rats. A daily dose of 40 micrograms or above, when administered from day 8 of pregnancy, suppressed serum progesterone levels within 48 h and by day 12 there was complete absence of live fetuses. Lower doses of antide (10-20 micrograms) reduced progesterone levels in circulation but were unable to induce abortion consistently in all treated rats. Administration of 150 or 300 micrograms of antide once on day 8 suppressed the progesterone levels within 24 h. Only a dose of 300 micrograms was effective in completely interfering with gestation by day 12 with no observable live fetuses.
在大鼠妊娠的前半期观察到了一种强效第三代促性腺激素释放激素（LHRH）拮抗剂[纳洛赖氨酸拮抗剂：安替肽]的作用。从妊娠第8天开始每日给予40微克或更高剂量，48小时内可抑制血清孕酮水平，到第12天时完全没有活胎。较低剂量的安替肽（10 - 20微克）可降低循环中的孕酮水平，但不能在所有接受治疗的大鼠中一致地诱导流产。在第8天一次性给予150或300微克安替肽可在24小时内抑制孕酮水平。只有300微克的剂量在第12天时能有效完全干扰妊娠，没有可观察到的活胎。
