Wernberg Jessica A, Yap Johnny, Murekeyisoni Christine, Mashtare Terry, Wilding Gregory E, Kulkarni Swati A
Department of Surgery, Marshfield Clinic, Marshfield, WI, USA.
J Surg Oncol. 2009 Jan 1;99(1):16-9. doi: 10.1002/jso.21153.
Male breast cancer (MBC) comprises 1% of all breast cancers and less than 1% of cancer cases in men. After a diagnosis of MBC, men are at risk of developing a second primary cancer, particularly a second primary breast cancer. The objective of this study is to analyze the characteristics of the population of men diagnosed with a second malignancy, specifically a second MBC.
Using the Surveillance, Epidemiology, and End Results (SEER) database, 4,873 male patients diagnosed with invasive or in situ breast cancer from 1973 to 2004 were identified and data from patients who developed a second MBC were reviewed. Additional non-breast primary cancer diagnoses were also recorded.
A review of 4,966 records corresponding to 4,873 patients revealed 4,462 invasive and 504 in situ breast cancer events. Of the 4,873 patients, 93 (1.9%) were identified with a second MBC. Among the 4,873 patients with MBC, 1,001 (21%) have other non-breast primary cancer diagnoses recorded in the SEER registry.
Although MBC is uncommon, these patients are at risk of a contralateral breast cancer and second primary non-breast cancers. Our findings support that men with breast cancer would benefit from continued long-term surveillance for breast cancer and appropriate screening for non-breast cancers.
男性乳腺癌（MBC）占所有乳腺癌的1%，在男性癌症病例中占比不到1%。确诊MBC后，男性有患第二种原发性癌症的风险，尤其是第二种原发性乳腺癌。本研究的目的是分析被诊断患有第二种恶性肿瘤，特别是第二种MBC的男性人群的特征。
利用监测、流行病学和最终结果（SEER）数据库，确定了1973年至2004年期间4873例被诊断患有浸润性或原位乳腺癌的男性患者，并对发生第二种MBC的患者数据进行了回顾。还记录了其他非乳腺癌原发性癌症诊断。
对对应于4873例患者的4966份记录进行回顾，发现4462例浸润性乳腺癌事件和504例原位乳腺癌事件。在4873例患者中，93例（1.9%）被确定患有第二种MBC。在4873例MBC患者中，1001例（21%）在SEER登记处有其他非乳腺癌原发性癌症诊断记录。
虽然MBC并不常见，但这些患者有患对侧乳腺癌和第二种原发性非乳腺癌的风险。我们的研究结果支持，乳腺癌男性患者将从持续的长期乳腺癌监测和适当的非乳腺癌筛查中受益。
