通过在超临界二氧化碳中进行分散开环聚合合成可生物降解的聚ε-己内酯微球。
Synthesis of biodegradable poly-epsilon-caprolactone microspheres by dispersion ring-opening polymerization in supercritical carbon dioxide.
作者信息
Grignard Bruno, Stassin Fabrice, Calberg Cédric, Jérôme Robert, Jérôme Christine
机构信息
Center for Education and Research on Macromolecules, University of Liege, Sart Tilman B6,4000 Liège, Belgium.
出版信息
Biomacromolecules. 2008 Nov;9(11):3141-9. doi: 10.1021/bm800730m. Epub 2008 Oct 21.
A series of fluorinated diblock and triblock copolymers of poly(epsilon-caprolactone) and poly(heptadecafluorodecylacrylate) were prepared by combining ring-opening polymerization of epsilon-CL and atom transfer radical polymerization of the acrylate. These copolymers with well-controlled molecular weight and composition were characterized by (1)H NMR spectroscopy and used as stabilizers for the dispersion ring-opening polymerization of epsilon-CL in supercritical carbon dioxide. The effect of composition and architecture of the polymeric stabilizers on the stabilization of PCL microspheres was investigated. Finally, purification of PCL was successfully implemented by reactive supercritical fluid extraction of the tin catalyst.
通过将ε-己内酯的开环聚合与丙烯酸酯的原子转移自由基聚合相结合，制备了一系列聚（ε-己内酯）和聚（十七氟癸基丙烯酸酯）的氟化二嵌段和三嵌段共聚物。这些具有良好控制的分子量和组成的共聚物通过¹H NMR光谱进行表征，并用作超临界二氧化碳中ε-己内酯分散开环聚合的稳定剂。研究了聚合物稳定剂的组成和结构对聚己内酯微球稳定性的影响。最后，通过对锡催化剂进行反应性超临界流体萃取，成功实现了聚己内酯的纯化。
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