State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
J Biomed Nanotechnol. 2010 Jun;6(3):287-92. doi: 10.1166/jbn.2010.1125.
Magnetic microspheres have promising application in biomedical field. In this paper, biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) triblock copolymers were synthesized by ring-opening polymerization method. Through adjusting the epsilon-CL/PEG weight ratio in feed, PCEC copolymers with different block ratio were obtained. A novel modified solvent diffusion method was described to prepare magnetic PCEC composite microspheres containing magnetite nanoparticles. The particle size of microsphere decreased with increase in the PEG/PCL block ratio. The obtained microspheres could response to external magnetic field. This study described a novel method to prepare magnetic microspheres. The obtained magnetic polymeric microspheres might have potential application in drug delivery system or disease diagnosis field.
磁性微球在生物医学领域有广泛的应用前景。本文采用开环聚合的方法合成了可生物降解的聚（ε-己内酯）-聚乙二醇-聚（ε-己内酯）（PCEC）三嵌段共聚物。通过调节原料中 ε-CL/PEG 的重量比，得到了不同嵌段比的 PCEC 共聚物。本文还描述了一种新型的改性溶剂扩散法来制备含有磁铁矿纳米粒子的磁性 PCEC 复合微球。微球的粒径随着 PEG/PCL 嵌段比的增加而减小。所得到的微球对外加磁场有响应。本研究描述了一种制备磁性微球的新方法。所得磁性高分子微球在药物传递系统或疾病诊断领域可能具有潜在的应用。
