Hartwig John F
Department of Chemistry, Yale University, PO Box 208107, New Haven, CT 06520-8107 (USA), Fax: (+1) 203-432-6144.
Angew Chem Int Ed Engl. 1998 Aug 17;37(15):2046-2067. doi: 10.1002/(SICI)1521-3773(19980817)37:15<2046::AID-ANIE2046>3.0.CO;2-L.
Oxidative addition and reductive elimination are the central steps in new palladium-catalyzed chemistry that forms C-N and C-O bonds in arylamines and ethers. In the potential mechanism shown on the right the amine is formed by reductive elimination from a four-coordinate, 16-electron amido aryl complex. The use of a chelating ligand such as 1,1'-bis(diphenylphosphanyl)ferrocene (DPPF) reduces the occurrence of the competing β-hydrogen elimination. X=Br, I; R, R'=alkyl, aryl.
氧化加成和还原消除是新型钯催化化学中的核心步骤，该化学过程在芳胺和醚中形成碳氮键和碳氧键。在右侧所示的可能机理中，胺是通过从四配位的16电子酰胺基芳基络合物中进行还原消除而形成的。使用螯合配体，如1,1'-双（二苯基膦基）二茂铁（DPPF），可减少竞争性β-氢消除的发生。X = Br、I；R、R' = 烷基、芳基。
