Mitchell S C, O'Gorman J, Waring R H
Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, London, England.
Drug Metabol Drug Interact. 1991;9(1):31-9. doi: 10.1515/dmdi.1991.9.1.31.
The fate of the three isomeric benzoic acid-substituted monochlorobenzanilides has been studied in the rat after their oral administration. The excretory profile of all three isomers was similar with over half of the dose being excreted in the 0-24 hour urine and between 83-87% being recovered during the three days following administration. The most prominent route of metabolism was that of 4'-hydroxylation on the unsubstituted aniline moiety followed by glucuronic acid conjugation.
三种异构体苯甲酸取代的一氯苯甲酰苯胺经大鼠口服给药后的代谢情况已得到研究。所有三种异构体的排泄情况相似，超过一半的剂量在0 - 24小时尿液中排出，给药后三天内回收率在83 - 87%之间。最主要的代谢途径是未取代苯胺部分的4'-羟基化，随后是葡萄糖醛酸结合。
